PATHOGENIC MICKOCOCCI 



Fio. 97. Micrococcus of 

 pyaemia in rabbits, in capil- 

 lary from the cortical portion 

 of the kidney. X700. (Koch.) 



13. MICROCOCCUS OF PY^MIA IN RABBITS. 



Obtained by Koch (1879) in rabbits inoculated 

 subcutaneously with putrefying flesh infusion. 



Morphology. Round cells, 0.25 u in diameter, 

 solitary or in pairs, which usually surround tHe 

 blood corpuscles in a characteristic manner. 



Biological Characters not given. 



Pathogenesis. When injected subcutaneously 

 in rabbits the blood is invaded and death occurs 

 from general infection. At the autopsv a puru- 

 lent infiltration is found at the point of injection, 

 there is peritonitis, and metastatic abscesses are 

 found in the lungs and liver. Numerous micro- 

 cocci, closely surrounding the blood corpuscles, 

 are found in the capillaries of the various organs, 

 the blood of the heart, etc. Two or three drops of 

 blood from the heart of a rabbit recently dead, in- 

 jected into another animal of the same species, 

 cause its death in about forty hours. 



14. MICROCOCCUS OF SEPTICAEMIA IN RABBITS. 



Obtained by Koch (1879) from rabbits inoculated subcutaneously with 

 putrefying flesh infusion. 



Morphology. Oval cells, haying a long diameter of 0.8 to 1.0 /*. 



Biological Characters not given. 



Pathogenesis. Produces general infection and death in rabbits and mice. 

 At the autopsy slight oedema is observed at the point of inoculation ; the 

 spleen is greatly enlarged ; no peritonitis and no embolic processes are found, 

 such as characterize the pathogenic action of the last-described species (No. 

 13) ; nor do the cocci accumulate around the red blood corpuscles. They are 

 found in the capillaries of the various organs in masses, and especially in 

 the glomeruli of the kidneys. 



15. MICROCOCCUS SALIVARIUS SEPTICUS. 



Obtained by Biondi (1887) from the saliva of a case of puerperal septicae- 

 mia, by inoculations into animals. 



Morphology. Spherical or slightly oval cocci, which, when in rapid mul- 

 tiplication, show slight lateral protrusions. 



Biological Characters. Grows in nutrient gelatin or agar at a tem- 

 perature of 18 to 20 C., and more rapidly in the incubating oven. Does not 

 liquefy gelatin. In gelatin plates forms spherical, grayish- white colonies, 

 which may acquire a dark color. In gelatin stick cultures grows along the 

 .line of puncture in the form of a column made up of crowded white colo- 

 nies. Very scanty growth on potato. 



Stains with all the aniline colors and by Gram's method. 



Pathogenesis. Produces general infection and death in from four to six 

 days when inoculated into mice, guinea-pigs, or rabbits. The cocci are 

 found in great numbers, often assembled in masses, in the capillaries of the 

 various organs, but no evidence of inflammatory reaction of the tissues is to 

 be observed. 



16. MICROCOCCUS SUBFLAVUS (Flligge). 



Synonym. Yellowish-white diplococcus (Bumm). 



Obtained by Bumm (1885) from the lochial discharge of puerperal women 

 and from vaginal mucus. Has also been obtained from the urine in cases 



