NOT DESCRIBED IN SECTIONS IV. AND V. 337 



Pathogenesis. Pathogenic for dogs and for horses. Intravenous injec- 

 tion of three to four cubic centimetres in dogs is said to produce symptoms 

 resembling those of distemper in this animal, viz., increased temperature, 

 catarrhal conjunctivitis, in some cases keratitis, and in some a mucous dis- 

 charge from the preputial sac. The micrococcus was not found in the blood 

 of the dogs inoculated by intravenous injection, later than the fourth day. 



40. STREPTOCOCCUS OF BONOME. 



Obtained by Bonome (1890) from the exudations of the cerebro-spinal 

 meninges and from haemorrhagic extravasations in the lungs in cases of 

 epidemic cerebro-spinal meningitis. 



This streptococcus is said by Bonome to be distinguished from previously 

 known streptococci by the following characters: It does riot grow readily 

 in artificial culture media, and soon loses its pathogenic power when pre- 

 served in a desiccated condition or cultivated through a few successive gene- 

 rations. It differs from the " pneumococcus " and " meningococcus " by 

 the ball- shaped appearance of its colonies on agar plates, and in the fact 

 that it does not grow upon, blood serum ; also by the difficulty experienced 

 in carrying it through five or six generations in artificial media. 



Pathogenesis. In white mice and in rabbits a fibrinous inflammation 

 and death result from inoculations with a pure culture, the symptoms re- 

 sembling those produced by similar inoculations with Micrococcus pneumo- 

 niae crouposse. It does not produce septicaemia in white mice, but in rabbits 

 the cocci are found in the blood in chains surrounded by a capsule. In 

 guinea-pigs and dogs a local fibrinous inflammation results from inocula- 

 tions, and the streptococcus is found in the gelatinous exudate at the point of 

 inoculation. It is distinguished from the streptococcus of erysipelas by its 

 failure to grow in gelatin or in blood serum, and by the appearance of its 

 colonies on agar plates. 



41. MICROCOCCUS OF ALMQUIST. 



Obtained by Almquist (1891) from the bullse of pemphigus neonatorum, 

 in nine children suffering from this disease during an epidemic which oc- 

 curred at Goteborg. 



Morphology. Micrococci from 0.5 to 1 ju. in diameter, usually in pairs. 



Stains readily with the aniline colors. 



Biological Characters. An aerobic, liquefying, chromogenic micro- 

 coccus. Closely resembles Staphylococcus pyogenes aureus in its morpho- 

 logy and growth in culture media. Produces a similar golden-yellow pig- 

 ment. 



Pathogenesis. According to Almquist, this micrococcus is distinguished 

 from Staphylococcus pyogenes aureus by its specific pathogenic power. Two 

 inoculations made from a pure culture, by means of a lancet, upon his own 

 arm gave rise to a development of bullse like those of pemphigus. The 

 process showed no disposition to extend deeper, but the epidermis was raised 

 by a collection of fluid which was at first transparent and later had a milky 

 opacity. From the contents of these bullae the same coccus was obtained in 

 pure cultures. 



42. STAPHYLOCOCCUS PYOSEPTICUS. 



Obtained by Hericourt and Richet (1888) from an abscess in the skin of a 

 dog. 



In its morphology and biological characters this micrococcus closely re- 

 sembles Staphylococcus pyogenes albus, and it is probably a pathogenic va- 

 riety of this common species. But the experiments made by the authors 

 referred to show it to be decidedly more pathogenic for rabbits. Subcutane- 

 ous injections of a drop or two of a pure culture caused an extensive inflam- 

 matory oedema, and death in from twelve to twenty-four hours. 



