IN SUSCEPTIBLE ANIMALS. 441 



Gelatin streak cultures. At the end of twenty-four hours this 

 bacillus had developed considerably, while the growth of the hog- 

 cholera bacillus was scarcely to be discerned with the naked eye, and 

 the bacillus of Schweineseuche did not form a visible growth until 

 the end of forty-eight hours. After several days the bacillus of 

 swine plague (Marseilles) formed an opaque, yellowish-white streak, 

 which, when examined with a low-power lens, had a brown color by 

 transmitted light and a bluish-white color by reflected light. The 

 streak of the Lomer-Schiitz bacillus was not so thick and not so 

 opaque, and was made up of small, nearly transparent colonies ; the 

 hog-cholera bacillus came between the other two. Upon blood 

 serum, agar, and glycerin-agar the Marseilles bacillus grew more 

 rapidly than the other two, forming a layer which was opaque and 

 of a white color, with bluish and reddish reflections. Upon potato 

 it formed a thick, opaque, yellowish layer, while the growth of the 

 hog-cholera bacillus was much thinner and that of the Loffler-Schutz 

 bacillus scarcely to be seen. In bouillon the Loffler-Schutz bacillus, 

 at the end of three days at 37 C., had not produced any perceptible 

 cloudiness, while the Marseilles bacillus at the end of twenty-four 

 hours had caused the fluid to be clouded, a film of bacteria had 

 formed upon the surface and a deposit at the bottom of the tube ; the 

 hog-cholera bacillus produced a less degree of opacity in the bouillon. 



Pathogenesis. This bacillus is pathogenic for sparrows and 

 other small birds when injected beneath the skin in small amounts, 

 and also for pigeons in a longer time five to fourteen days. Frosch 

 reports a negative result from subcutaneous injections into rabbits, 

 guinea-pigs, mice, and pigeons, but his cultures appear to have be- 

 come attenuated, as the recent cultures of Eberth and Schimmelbusch 

 were fatal to pigeons in four out of five experiments. Two rabbits 

 were inoculated subcutaneously by Rietsch and Jobert with half a 

 Pravaz syringef ul of a pure culture of the Marseilles bacillus ; one of 

 these died on the sixth day and the other survived. 



In sparrows, which succumb in from twenty-four to thirty-six 

 hours after receiving a small amount of a pure culture in the breast 

 muscle, the bacillus is present in the blood in large numbers, and a 

 purulent pleuritis and pericarditis is found at the autopsy. In the 

 ferrets from which Eberth and Schimmelbusch obtained their cultures 

 the bacillus was not present in the blood in sufficient numbers to be 

 readily demonstrated by microscopical examination, but it was ob- 

 tained in pure cultures from the liver, spleen, and lungs. The prin- 

 cipal pathological appearances noted were enlargement of the spleen 

 and pneumonia. Caneva reports that the Marseilles bacillus injected 

 into white mice gives rise to an extensive abscess at the point of in- 

 oculation, but does not kill adult animals. In a young mouse which 

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