BACTERIA IN INFECTIOUS DISEASES. 575 



lococcus pyogenes aureus in 10, Staphylococcus pyogenes albus in 9, 

 and Staphylococcus pyogenes citreus in 3. 



Later researches indicate that, as a rule, the pus cocci are not 

 present in the pus from an unopened inguinal bubo following chan- 

 croid. In this regard Ducrey, Krefting, and Spietschka are in ac- 

 cord. The last-named author also arrives at the conclusion that the 

 streptobacillus found in chancroidal ulcers is not present in the pus 

 of unopened buboes, and that this is not virulent. Inoculation ex- 

 periments with such pus gave a negative result, and the most careful 

 microscopical investigation failed to reveal the presence of micro- 

 organisms of any kind. Cheinisse (1894) also had a negative result 

 from inoculations with the pus from buboes except in one case in 

 which the bacillus of Ducrey was, by exception, demonstrated to be 

 present. He finds that while the pus from unopened buboes is 

 usually sterile it sometimes contains the ordinary pyogenic micro- 

 cocci. 



BUBONIC PLAGUE. 



The bacillus found by Kitasato (1894) and by Yersin (1894) in the 

 contents of the buboes and in the blood of infected animals is no 

 doubt the cause of this infectious malady (see No. 166). 



CARCINOMA. 



Various bacteria have occasionally been found in carcinomatous growths, 

 and especially in those which have undergone ulceration ; but that any one 

 of these bears an etiological relation to such malignant tumors has not been 

 demonstrated. 



CEREBRO-SPINAL MENINGITIS. 



Various microorganisms have been found by bacteriologists in the 

 exudate of cerebro-spinal meningitis, and there seems to be but little 

 doubt that the meningeal inflammation is due to their presence, as 

 the bacteria usually found are pathogenic for certain of the lower 

 animals, and when introduced into a serous cavity they give rise to 

 a fibrinous or purulent inflammatory process. The researches of 

 Weichselbaum, Netter, and others show that Micrococcus pneu- 

 monia crouposa3 (" diplococcus pneumonia ") is the microorganism 

 most frequently found, and next to this the Diplococcus intercel- 

 lularis meningitidis of Weichselbaum. Streptococcus pyogenes has 

 also been found in a certain proportion of the cases four out of 

 twenty-five cases of purulent meningitis studied by Netter. 



Bonome, in a series of cases studied by him, obtained a micro- 

 coccus closely resembling Micrococcus pneumonia crouposa3, but 



