436 PATHOGENIC BACTERIA. 



Pawlowsky and others have found that the dog is sus- 

 ceptible to cholera, and have utilized the observation to 

 prepare an antitoxic serum in considerable quantities. 

 The dogs were first immunized with attenuated cultures, 

 then with more and more virulent cultures, until a serum 

 was obtained whose value was estimated at 1 : 130,000 

 upon experimental animals. 



Freymuth^nd others have endeavored to secure favor- 

 able results from the injection of blood-serum from con- 

 valescent patients into the diseased. One recovery out 

 of three cases treated is recorded — not a very glittering 

 result. 



In all these preliminaries the foreshadowing of a future 

 therapeusis must be evident, but as yet nothing really 

 satisfactory has been achieved. 



Spirilla resembling the Cholera Spirillum. 

 The Finkler and Prior 2 Spirillum (Vibrio Proteus). — 



Somewhat similar to the spirillum of cholera, and in 

 some respects closely related to it, is the spirillum ob- 

 tained from the feces of a case of cholera nostras by 

 Finkler and Prior in 1884. It is a shorter, stouter or- 

 ganism, with a more pronounced curve than the cholera 

 spirillum, and rarely forms the long spirals which char- 

 acterize the latter. The central portion is also somewhat 

 thinner than the ends, which are a little pointed and 

 give the organism a less uniform appearance than that 

 of cholera (Fig. 92). Involution-forms are very common 

 in cultures, and occur as spheres, spindles, clubs, etc. 

 Like the cholera spirillum, each organism is provided 

 with a single flagellum situated at its end, and is actively 

 motile. Although at first thought to be a variety of the 

 cholera germ, marked differences of growth were soon 

 observed, and showed the organism to be a separate 

 species. 



The growth upon gelatin plates is quite rapid, and leads 

 to such extensive liquefaction that four or five dilutions 



1 Deutsche med. Wochenschrift, 1893, No. 43. 2 Ibid., 1884. 



