ANAPHYLAXIS OR HYPERSUSCEPTIBILITY 3S 



phylactic shock in the administration of serum for 

 therapeutic purposes. Rosenau and Anderson point 

 out that anaphylaxis is to be feared in all persons who 

 have shown a tendency to astlima, or who have received 

 previous injections of serum at least twelve days be- 

 fore. In these persons it is well to make a preliminary 

 injection of a small trial dose of 0.1 to 0.2 c.c. of serum, 

 and if no symptoms appear within two hours, the full 

 dose may be given. 



Serum Sickness. — The symptoms, grouped under 

 the term " serimi sickness," occasionally seen after the 

 injection of antitoxic serum in diphtheria and other 

 diseases, are for the most part manifestations of ana- 

 phylaxis. These symptoms usually consist in fever, 

 urticarial eruptions, lymphatic nodal enlargements, 

 and kidney irritation. Usually these symptoms are 

 transitory, but fatal cases have been reported. In 

 order for these phenomena to follow a single injection, 

 as occasionally happens, a large dose of serum must be 

 employed; but the appearance of symptoms may occur 

 after a very small second injection. The mild cases of 

 serum sickness require no special treatment. With the 

 refinement of preparation and concentration in small 

 bulk of antisera, untoward symptoms following in- 

 jection have become comparatively rare. 



