ANTIBACTERIAL SERA 61 



demic cerebrospinal meningitis due to the Diplococcus 

 intracellularis has been reduced from 70 per cent, to 

 about 30 per cent. 



The antimeningococcic serum may also be used as 

 a preventive measure in persons exposed to the disease. 



Antityphoid Serum. — Antibacterial sera have been 

 prepared by immunizing horses by injections of mixed 

 strains of killed and live typhoid bacilli. The serum 

 thus produced has been injected into persons suffering 

 from typhoid fever, in daily doses of 10 c.c. or more. 

 So far the results have been disappointing either in 

 shortening the disease or lessening the severity of the 

 symptoms. For protective purposes, active immu- 

 nization by injection of killed cultures of typhoid 

 bacilli has proved more successful. 



Anticolonic Serum. — Hans ]Much finds that nor- 

 mal blood-serum has a bactericidal action upon certain 

 strains of colon bacilli, while on other strains blood- 

 plasma has this action but not blood-serum. He has 

 employed normal blood-plasma and serum locally in 

 cystitis caused by infection with the colon bacillus with 

 some success. Much has also been able to produce a 

 powerful specific antiserum by injecting animals with 

 several strains of colon bacilli, which have bacteriolytic 

 properties against all strains of colon bacilli. He has 

 used this also with benefit as a local application in 

 colon bacillus pyelitis and cystitis. 



