68 APPLIED IMMUNOLOGY 



marked benefit, in 5 there was distinct benefit, while 

 5 were apparently cured. The autolysates were made 

 by mincing fetal and embryonic tissues, placing them 

 in normal salt solution and incubating for two months. 

 The clear fluid was then injected subcutaneously or 

 directly into the neoplasm. Recently, Babcock {In- 

 ternational Clinics^ Vol. II, 23rd Series, 1913) has 

 reported a trial of fetal autolysates prepared by 

 Fichera's method in 21 cases of recurrent or inoper- 

 able cancer, and concludes that this method is of no 

 distinct value in the treatment of malignant disease in 

 man. It would seem, therefore, that Fichera's treat- 

 ment is doomed to the same failure that has so far 

 attended all other attempts at cure of carcinoma by 

 organo- or serum therapy. 



Pyocyanase, — Pyocyanase is a ferment isolated 

 from cultures of B, pyocyaneus, said to have high di- 

 gestive powers for proteids. It has been employed 

 in the treatment of diphtheria, the protein digestive 

 action facilitating the removal of the membrane. Pyo- 

 cyanase has also been used in gonorrhoeal urethritis, 

 in follicular tonsillitis and as a spray for disinfection 

 of the nose. 



Antithyroid Serum and E attracts, — Working 

 upon the established theory that the symptoms of ex- 

 ophthalmic goitre were due to a hypersecretion of the 



