178 



APPLIED IMMUNOLOGY 



addition to a rise in temperature of at least one degree, 

 increased focal inflammatory signs, located in the 

 lungs, bones, joints, epididymis or wherenot (Figs. 

 15 and 16). Considerable importance is to be at- 

 tached, also, to the inflammatory areola ofttimes sur- 

 rounding the site of injection (local reaction). Ob- 



FiG. 16. — R. W. S. Bilateral tuberculous epididymitis. Observe the suggestive 

 rise in temperature after the first injection of tuberculin, not to be regarded, however, 

 as pathognomonic, owing to the absence of any focal reaction. The reaction occurring 

 on the thirteenth of the month is typical generally, focally and locally. 



viously, a focal reaction outweighs in significance both 

 the general and local reactions, and under such cir- 

 cumstances a positive test may be pronounced even 

 though the febrile rise has not amounted to a degree. 

 The sites commonly chosen for the injections are the 

 outer or posterior aspects of the arm, the supra- or 

 interscapular areas, the outer aspects of the thigh or 



