196 APPLIED IMMUNOLOGY 



greater and the toxic effect is less; some still adhere 

 to " O. T." or its bovine preparation according to 

 Spengler; a few have faith in Dixon's product and 

 many have been impressed by the virtue of " T. P.," 

 which Neumann has shown to be the least toxic, hence 

 to be preferred in febrile cases or when the process of 

 immunization is to be effected in the shortest possi- 

 ble time. The ideal modus operandi would appear to 

 be a combination or alternation of " B. E." and 

 " B. F.," the former consisting of the bacilli and their 

 extractives inactivated by a minimal degree of heat, 

 the latter comprising the unheated filtered toxins of 

 the bacilli; thus the patient would seem to be im- 

 munized against all constituents of the bacillus. A 

 number of attempts have been made to employ so- 

 called modified tubercle bacilli in the treatment of 

 tuberculosis. The most recent failure of this nature 

 was the well-advertised " Friedmann Cure " or inocu- 

 lation with non-virulent turtle tubercle bacilli. 



Modes of Administration and Dosage, — The usual 

 method of administering tuberculin to patients is by 

 subcutaneous inoculation (for technic see Chapter 

 XV, p. 178). In the case of " B. E." and " T. R.," 

 the common initial dose may be 0.001 milligramme ; ^ 

 with Dixon's tuberculin, the beginning inoculation 



^ A few clinicians utilize and recommend the superiority of infinitesi- 

 mal doses in tuberculin therapy, namely, an initial inoculation of 

 0.0000001 to 0.000000001 milligramme of " B. E." or " O. T." 



