260 



APPLIED IMMUNOLOGY 



smallpox and bubonic plague, by all odds furnishes 

 the most fertile field for bacterial inoculations, thera- 

 peutically and prophylactically. 



Acne. — Extraordinary results have followed bac- 

 terin therapy in this disease, especially in the pustular 

 variety, when usually the M. alhus, but occasionally 

 the M, aureus and rarely the M, citreus, have been 

 isolated (Fig. 39). Incipient or non-pustular acne, 



Fig. 39. — Harris E. T. Case of long-standing and obstinate pustular acne vulgaris. 

 Yielded to autogenous bacterin therapy only after a prolonged course of treatment. 



according to the researches of Unna and Sabouraud 

 caused by the Bacillus acnes, is in many cases favor- 

 ably influenced by inoculations with this organism, al- 

 though the results are not nearly so brilliant as with 

 the staphylococci in the pustular form of the disease. 

 Sabouraud contends that the acne bacillus is also the 

 cause of sehorrhoea and alopecia areata, and Fleming 

 has reported signal successes in the treatment of these 

 conditions with B. acnes bacterin. In the treatment of 



