294 APPLIED IMIVIUNOLOGY 



the B, 'pyocyaneus, the B, acidi lactici and rarely the 

 Bacillus of Friedldnder. Bacterin therapy, especially 

 using autogenous suspensions of the first three named 

 organisms, has in many cases been productive of good 

 results. The initial dose had best be smaller than 

 the average and here the utilization of the opsonic 

 index as a control of treatment will prove service- 

 able. In not a few cases no material benefit has 

 followed the use of bacterins. 



Typhoid Fever. — Inasmuch as the lesions of the 

 intestines stand out conspicuously in the pathology 

 of this disease and are the organs first concerned by 

 the invading microbe, the B, typhosus, it may be 

 permissible to discuss its therapy under this heading. 

 In the first place, it will be recalled that not infre- 

 quently by bacteriological study the fever will be 

 found to be due to an organism closely allied to the 

 bacillus of Eberth, namely the B, paratyphosus A or 

 B or the paracolon bacilli, hence the advisability of 

 accurate bacteriological investigation if this disease 

 is to be treated biologically. A number of observers 

 have reported favorably as to mortality complications 

 and relapses by bacterial inoculations. In spite of 

 the fact that after the first two or three days a bac- 

 tersemia supervenes, enduring for a number of days 

 or weeks, a strong movement is in progress relative 

 to the routine employment of typho-bacterin in 



