298 APPLIED IMMUNOLOGY 



Dysentery. — Bacterin therapy concerns only the 

 bacillary type of this disease. Closely allied bacilli 

 have been described by Kruse, Shiga, Flexner, Hiss 

 and Strong. Bacterial inoculations, employing 

 mostly the Kruse- Shiga type of organism, have been 

 extensively used in all save the acute gangrenous form 

 of the disease, with the result that the mortality has 

 fallen from 6.3 to 0.9 per cent. It should be noted 

 that in acute cases bacterin therapy is contra-indicated 

 from the fourth to the twenty-first day. During this 

 period Kruse and Shiga's anti-endotoxic serum should 

 be administered in full doses. 



Cholera. — Bacterin therapy in this disease is 

 limited entirely to preventive inoculation; it is value- 

 less in a cm-ative capacity. Since the introduction of 

 prophylactic inoculations with the vibrio cholerse, the 

 incidence of the disease in a study of thousands of 

 uninoculated and inoculated cases has fallen from 3.6 

 to 0.66 per cent. Three immunizing doses of 500, 1000 

 and 1000 million spirilla respectively are administered 

 at intervals of about ten days. 



Diseases of Cardiovascular, Lymphatic and Nervous 

 Systems, also Other Acute Specific Fevers 



Bactercemia, Septicoemia and Pycemia, — It is our 

 belief, for reasons previously stated under " Contra- 

 indications," that bacterial inoculations, in these con- 



