302 APPLIED IMMUNOLOGY 



Allusion, however, should be made to the more 

 recent work of Semple and Harris, who have prepared 

 efficient vaccines from the medullas of rabbits, which 

 will keep for long periods and are constantly ready 

 for use, thereby obviating the elaborate methods of 

 Pasteur. Harris in particular has reported on the in- 

 transpinal injection in animals of 0.1 milligramme of 

 powder obtained from the pulverized frozen brain and 

 cord of animals killed by a fixed virus. This prepara- 

 tion is dried in vacuo over sulphuric acid at a low tem- 

 perature. It is claimed to produce immunity in a few 

 hours or days, instead of weeks, and can be preserved 

 in sealed tubes indefinitely. Further investigation is 

 necessary to determine whether or not Harris' 

 preparation is to supplant the more familiar " Pasteur 

 Treatment." 



Malignant Neoplasmata 



All attempts to produce an efficient tumor extract 

 or emulsion for the treatment of carcinoma and sar- 

 coma have proved futile. A few years ago Doyen 

 proclaimed the specificity of the Micrococcus neo- 

 formans in the etiology of cancer. This organism is 

 midoubtedly an accidental invader, and to the best of 

 our knowledge no case of carcinoma has been or will 

 be cured by the agency of neoformans bacterin. 



Coley's treatment of sarcoma is worthy of mention. 



