326 APPLIED IMMUNOLOGY 



ished by 0.1 gramme for women. In children the dosage 

 should be proportionate to the age. Syphilitic new-born 

 infants should receive from 0.02 to 0.1 gramme of the 

 drug. 



Neosalvarsan, although less toxic, is unfortunately also 

 less effective than its predecessor, salvarsan. The average 

 adult dose is 0.9 gramme, corresponding in arsenical con- 

 tent to 0.6 gramme of salvarsan. Commercially it is 

 marketed in ampoules with the following proportionate 

 dosage: 



The last three doses are for veterinary purposes only and 

 have no place in human therapeutics. 



The repetition of the dose is dependent upon the method 

 of administration (intravenous or intramuscular), the or- 

 ganic condition of the patient and his susceptibility to reac- 

 tionary phenomena. Usually when injected intravenously, 

 the doses are repeated in five to ten days in the absence 

 of reactionary contra-indications. In some cases weekly ad- 

 ministration of 0.6 gramme of salvarsan intravenously for 

 several weeks has been unproductive of harmful effect. The 

 policy should be, particularly in early syphilis, to produce 

 an intensive or specific effect by repeated intravenous injec- 

 tions until a negative Wassermann reaction is obtained. It 

 is seldom that less than three administrations are necessary 



