INDUCTION AND IMMUNITY 



with kaolin, barium sulphate. The literature of this subject is exten- 

 sive. The most important contributions recent have hem m;i<le by 

 I'.ordet, iMoldovan and l)oerr, ls and Novy and DeKruiff. 1 '' All of 

 these investigations tend to show that guinea pig scrum can acquire, 

 strongly toxic properties when treated with any form of substance 

 in line suspension, whether this be living or dead bacteria, or pro- 

 tozoa, or indifferent materials such as agar, kaolin, etc. Further- 

 more, the direct injection of very dilute solutions of agar, etc., into 

 guinea pigs and rabbits may cause fatal symptoms closely resembling 

 anaphylaxis. Moreover, it has been shown by a number of workers 

 that blood taken from guinea pigs and rabbits, either defibrinatcd 

 or rent rifuged and reinjected before the dotting was complete, could 

 exert similar toxic action. We believe that these anaphylatoxin 

 phenomena are of very great importance, that they represent a 

 phenomenon dependent upon very delicate adjustment of the col- 

 loidal conditions prevailing in the circulating blood, and demon- 

 strate the possible dangers accruing from the disturbance of such 

 conditions, a matter which has been particularly emphasi/ed by 

 Jobling and .IVtersen.- 1 " But, we do not believe that the ana- 

 phylatoxin phenomena bear a direct relationship to the processes 

 that we may classify under true anaphylaxis. The demonstration 

 of the cellular Localization of the mechanism which causes true 

 anaphylactic shock has, we believe, amply demonstrated this. 



SERUM SICKNESS. The injection of foreign proteins into human 

 beings, especially in the form of horse scrum as in antitoxin treat- 

 ment, causes a train of symptoms which are classified together as 

 serum sickness. We will not go into the history of serum sickness, 

 however interesting, and refer the reader to larger works on the 

 subject, the summaries of anaphylaxis mentioned above, as well as 

 the book of Von Pirquet and Schick, "Die Serum Krankheit," 

 Vienna, 1905. A peculiarity of this condition is that it may follow 

 the first injection of horse serum or any other foreign protein, as 

 well as subsequent ones. 



After first injection, the incubation period may last as lonii as 

 twelve days, or longer, although it may be considerably shorter than 

 this, ('oca states that in 24 to 48 per cent of all cases the incubation 



:in.l />O,/T. /.-it. f. ImiiMinitiit.. 7, UNO. 

 Novy and DeKruiff, Jour. A. M. A., (is, 1!>I7, 1524. 

 80 Jobling and Petersen, Jour. Expci. M,-,!., i, 11)14, No. 5. 



