OTHER BACILLI OF THE FRIEDLANDER GROUP 725 



dextrose bouillon, in producing no acid in lactose bouillon, and in 

 never coagulating milk. 



Pathogenicity. The bacillus of rhinoscleroma is but moderately 

 pathogenic for animals delicately susceptible to the bacillus of Fried- 

 lander. Rhinoscleroma, the disease produced by this bacillus in man, 

 consists of a slowly growing granulomatous inflammation, located 

 usually at the external nares or upon the mucosa of the nose, mouth, 

 pharynx, or larynx. It is composed of a number of chronic, hard, 



FIG. 72. BACILLUS OF RHINOSCLEROMA. Section of tissue showing the micro- 

 organisms within Mikulicz cells. (After Frankel and Pfeiffer.) 



nodular swellings, which, on histological examination, show granu- 

 lation tissue and productive inflammation. In the meshes of the 

 abundant connective tissue lie many large swollen cells, the so-called 

 ' ' Mikulicz cells. ' ' 14 The rhinoscleroma bacilli lie within these cells 

 and in the intercellular spaces. They can be demonstrated in his- 

 tological sections and can be cultivated from the lesions, usually 

 in pure culture. Rhinoscleroma is rare in America. It is most 

 prevalent in Southeastern Europe. The disease is slowly progressive 

 and comparatively intractable to surgical treatment, but hardly ever 

 affects the general health unless by mechanical obstruction of the 

 air passages. 



14 Mikulicz, Arch. f. Chir., xx, 1876. 



