DISEASES CAUSED BY SPIROCH.ETES 873 



Spirochaeta macrodentium. Cultivated by Noguchi ; 64 is believed 

 by him to be identical with the spirochaete found in Vincent 's angina. 



Spirochaeta microdentium. A similar organism with wide con- 

 volutions, cultivated by Noguchi from the tooth deposits chiefly in 

 children. It was grown on mixtures of sheep serum water and 

 sterile tissue in a way similar to that employed by him for other 

 organisms of this group. 



Spirochaeta calligynun, Cultivated by Noguchi 65 from condy- 

 lomata is probably a new species. 



Rat-Bite Fever. Rat-bite fever is a peculiar disease, which, 

 after an incubation period of ten or more days, is characterized 

 by fever, headache and inflammation at the site of the bite, swollen 

 lymph glands, skin eruption and pains. After three to six days 

 the fever ceases and an afebrile period of two or three days ensues. 66 

 After this the fever again occurs. Recently Futaki, Takaki, Taniguchi, 

 and Osumi 67 have described a treponema which they have called 

 Treponema morsus muris. It is a spiral organism, somewhat larger 

 than the Treponema pallidum, and is found in the skin, the lymph 

 nodes, and in the blood. They have succeeded in inoculating rats 

 and have cultivated it in Schimamine medium, which consists of 

 100 c.c. of horse serum in which 0.5 to 0.75 gram of sodium nucleate 

 is dissolved and carbon dioxide passed through the solution until 

 the serum becomes transparent. It is then heated for three days 

 at 60, and on the fourth day at 65 until it coagulates. This 

 medium is deeply inoculated, but no other anaerobic precautions are 

 taken. 



"Noguchi, Jour. Exp. Med., xv, 1912. 



65 Noguchi, Jour. Exp. Med., xvii, 1913. 



66 In connection with Eat-Bite Fever see also Kaneko and Okuda, Journal 

 Exp. Med., vol. xxvi, 1917, p. 363. 



67 Jour. Exp. Med., 1916, xxiii, p. 249. 



