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1059 



edcmatous epithelial cells. A little attention to the nucleus will 

 prevent this error, since the tissue-cell nucleus is large, distinct, and 

 entirely different from the nucleus of an amoeba. 



In specimens stained with hematoxylin the finer details, especially 

 in the nucleus, may be studied, but stained preparations are never 

 necessary for clinical diagnosis. In smears from fresh cases vegeta- 

 tive forms only are found, later many degenerative forms appear 

 and during convalescence only cysts may be seen. In stained speci- 

 mens there is rarely any separation of ectoplasm and endoplasm, 

 but the nucleus is always visible. The cytoplasm is granular and 

 has a coarse honey-combed appearance. The nucleus shows a dis- 



FIG. 123. ENTAMCEBA HISTOLYTICA. 

 (Army Med. School Collection, Wash- 

 ington, D. Cj 



FIG. 124. ENTAMCEBA HISTOLYTIC. 

 (X 1150) Cyst, showing four nuclei, 

 two of which are very distinct, and 

 large chromatoid body. (Army Med. 

 School Collection, Washington, D. C.) 



tinct, though delicate, limiting membrane, on the inner surface of 

 which are few or many chromatin dots. In the center is a small 

 karyosome, which may show a central body or centriole. The outer 

 zone of the nucleus has a honey-comb structure, in which are im- 

 bedded granules of chromatin. 



Multiplication in the vegetative stage is by division into two 

 daughter cells ; in the intestinal contents, it is difficult to find forms 

 which are undergoing division, but a few have been described 

 and pictured. In experimental dysentery, in the cat, however, all 

 stages of the process may be followed by removing the intestine 



