MAST1GOPHORA 1091 



(Brit. Med. Jl., 1920, 235). Other arsenical preparations have been 

 used but none are entirely successful. Salvarsan drives the parasite 

 from the peripheral blood but not from the cerebro-spinal fluid. The 

 prognosis as to ultimate recovery is unfavorable. The most hopeful 

 cases are those which are brought under treatment in the earliest 

 stage of the disease. 



Prophylaxis. Prophylaxis is quite complicated and is carried out 

 along several different lines. Infected fly belts are depopulated, the 

 inhabitants being removed to a fly-free district where they may be 

 treated at hospital stations. The fly breeding may be greatly 

 diminished by clearing off the forest and brush, especially along the 

 river courses, since the glossina needs abundant moisture for its propa- 

 gation. Since the fly bites only during the day, all traveling in 

 infected districts is best done at night. A prophylactic measure of 

 prime importance is the search for and the treatment of the cases, 

 which are also carriers. While the treatment may not cure, it does 

 bring about improvement and lessens the number of heavily infected 

 carriers. 



Trypanosome cruzi, Chagas (Schizotrypanum cruzi). This para- 

 site, which differs from all other trypanosomes, is the cause of a 



FIG. 142. SCHIZOTRYPANUM CRUZI IN HUMAN BLOOD. (From Doflein after 

 Chagas. MacNeal, "Pathogenic Microorganisms," published by P. Blakis- 

 ton's Son & Co.) 



form of human trypanosomiasis occurring in Brazil. It is trans- 

 mitted by a bug, Triatoma magista (Conorkinus megistus), in which 

 the parasite passes part of its cycle of development. Brumptf believes 

 the infection is transmitted by the dejecta of the bug as well as by 

 its bite, and thinks the first method is probably the more usual 

 one. In the human being, multiplication takes place in endothelial 

 cells, lymphocytes and parenchymatous cells of the viscera ; and also 

 in the skeletal and heart muscles. While in this stage the parasite 



| Brumpt, Bull, Acad. Med., Paris, 1919, 81, 251. 



