228 CLINICAL BACTERIOLOGY. 



STRONG ANTITOXIN OF 500 TIMES THE NORMAL STRENGTH. 



Number o D, yellow, 

 Number 2. D, white, 

 Number 3 D, red, . 

 Number 4 D, violet, 

 Number 6 D, blue, . 



1 cu. cm. contains 500 immunity-units. 



2 " contain 1,000 " 



3 " " 1,500 



4 " " 2,000 



6 " " 3,000 



ANTITOXIN OF 600 TIMES THE NORMAL STRENGTH. 

 Number 6s, blue, . . 5 cu. cm. contain 3000 immunity- units. 



The Pasteur Institute, of Stuttgart, manufactures only 

 one preparation of 50,000 Roux immunity-units. 



The Schering factory produces the following antitoxins : 



A, loo immunity-units per cu. cm. 



B, 200 " " " (in vials of 5 and 10 cu. cm.). 

 Strong antitoxin of 500 times the normal strength, 500 immunity- 

 units per cu. cm. (in vials of 2 and 4 cu. cm.). 



The Hamburg establishment dispenses diphtheria-anti- 

 toxin prepared by Ruete and Enoch and containing 300 

 immunity-units per cu. cm. 



In injecting the serum the rubber-ball syringe of Koch 

 may be employed, and this is easily manipulated by one 

 who is experienced. (Fig. 36, 2.) The antitoxin-syringe of 

 Roux is to be recommended as especially practical, and 

 it can be sterilized with the greatest ease. (Fig. 36, i.) It 

 is either boiled in a one per cent, solution of soda, or it is 

 cleansed with a five per cent, solution of carbolic acid, after 

 which it is rinsed with a o. 5 per cent, solution in order that 

 the antitoxin may not be injured in consequence of too 

 great concentration of the antiseptic. 



The number of immunity-units to be injected in the 

 individual case will depend entirely upon its severity, and 

 upon the day of the disease that the patient comes under 

 treatment. In a mild case, coming under observation on 

 the first day, 600 immunity-units will suffice. Severe 

 cases, seen as late as the third day, will require 1000 im- 

 munity-units. In still more severe cases, seen at a late 

 stage, 1500 immunity-units and more are employed. 



The results that have thus far been obtained in the 

 treatment of diphtheria with the antitoxin have been ex- 

 ceedingly favorable. The mortality from diphtheria has 

 been reduced about half under the influence of the antitoxin. 

 In support of this statement we may quote the results of 



