378 CLINICAL BACTERIOLOGY. 



site loses its previous torpid motility, becoming spherical 

 and filling the blood-corpuscle one-third or one-half. It 

 then continues to grow slowly until it has attained the full 

 size of the blood-corpuscle, so that no portion of this 

 remains visible, and the parasite appears to be free. Sporu- 

 lation now takes place, the pigment-granules concentrating 

 at the center, while a radiate striation makes its appear- 

 ance in the plasma, first at the periphery, subsequently 

 also at the center, gradually becoming more distinct and 

 dividing the parasite into from eight to twelve segments. 

 These segments separate more distinctly from one another 

 as oval bodies (daisy-form), and each contains a bright 

 spot the nucleolus. Spore -formation is now completed, 

 and the spores are set free by rupture of the mother-cell. 

 The entire process of development has occupied seventy- 

 two hours. Segmentation takes place before and during 

 the febrile attack. About three hours before the occur- 

 rence of the chill the first complete sporulation-bodies are 

 visible in the blood. The red blood-corpuscles that have 

 been infected with quartan parasites do not undergo change 

 in size. The parasites at times progress to sporulation 

 before they have attained the size of the blood-corpuscle. 

 They then generally give rise to from four to six spores. 

 The extrusion of flagella is observed seldom and only in 

 the younger forms. 



In the regular progress of development of the quartan 

 parasites it is relatively easy to distinguish several genera- 

 tions from one another when these are present. 



The quartan parasite induces typical quartan fever 



(lOOiooiooi) ; two or three generations separated by an 

 interval of twenty-four hours give rise to double quartan 



(120120120) or triple quartan (123 123 123). The last 



may be considered a false quartan. If several generations 

 of the quartan parasite are present whose development is 

 separated not by intervals of twenty-four hours, but by 

 shorter or longer intervals, irregular types of fever re- 

 sult. 



2. The tertian parasite completes its cycle of develop- 

 ment within forty-eight hours. The juvenile form re- 

 sembles that of the quartan parasite : presenting a small 

 plasmic body, with a nucleus free from pigment, in the living 



