THE LIVER 



413 



treated with LugoFs solution of iodin after alcoholic fixation. The 



amount of glycogeri present varies with the diet. After digestion and 



absorption of a carbohydrate 



meal it is greatly increased, but 



disappears during fasting. Even 



when glycogen is quite deficient, 



the hepatic cells still present a 



granular appearance from the 



presence of other substances, 



possibly zymogens. 



FAT GLOBULES. Fat glo- 

 bules occur in hepatic cells in 

 limited numbers; and appear to 

 be a normal constituent. The (Adapted from Merkel. ) 



globules vary much in size, but 



are all very small. Their number is also dependent upon diet and diges- 

 tion. During absorption of a fatty meal, fat globules occur in consider- 

 able numbers, and are most numerous in those hepatic cells which are 



Blood capillary 



Bile capillary 



Lymph space 



Nucleus 



FIG. 386. DIAGRAM OF FOUR ADJACENT 

 LIVER CELLS. 



FIG. 387. ISOLATED LOBULES OP THE PIG'S LIVER. X12.5 

 (After F. P. Johnson; Am. Jour. Anat., Vol. 23, 1918.) 



at the periphery of the lobule. They are not normally found in the 

 vicinity of the central vein. 



The hepatic cells also frequently contain brown or yellowish-brown 



