^2 GENERAL PART 



internal secretions of what is ordinarily known as the ductless glandular 

 system does not preclude its influencing by products of cellular activity 

 elaborated in the course of diseases that have nothing to do with the ductless 

 glandular system (I am indebted for this idea to remarks by McCarthy, in 

 an extempore address) or in which, as in the infectious diseases, the ductless 

 glandular system is influenced only indirectly. This subject last mentioned, 

 that of ductless glandular affection in the course of infectious disease has been 

 taken up especially by Sajous, to whom we are indebted so much for attract- 

 ing our attention to the importance and scope of ductless glandular affections. 



What is especially noticeable in the ductless glandular diseases is the 

 employment of chemical substances or glandular extracts in their diagnosis 

 a use for these substances or extracts that independently of the ameliorative 

 effect is perhaps new in the art of diagnosis, and that may perhaps mark 

 the beginning of a new science, that of pharmacodiagnosis. 



Sajous has recently published a resume of his conclusions with regard to 

 the function of the various constituents of the ductless glandular system. 

 This resume approaches first principles to a greater extent than any of 

 Falta's conclusions, and is interesting as furnishing a basis of comparison 

 with the results of Falta's work. Sajous maintains that the thymus gland 

 supplies to all tissues the excess of phosphorus in organic combination 

 (possibly as nucleins) required to build up cell-nucleins while the animal or- 

 ganism is developing. The thyroparathyroid secretion (thyroidase) sensitizes 

 these nucleins to the action of oxygen. The adrenal secretion (through its 

 catalytic ferment, adrenoidase) endows the blood with its oxygenizing prop- 

 erties. The pancreas supplies the ferments which in the intestinal canal and 

 nutritional leucocytes change food materials into products harmonious to, 

 and for the building up of, tissue cells, that is, for the anabolic phases of 

 metabolism. The same pancreatic ferments also carry on the catabolic 

 phase of metabolism. All endogenous and exogenous substances that are 

 not appropriate for tissue-building bacteria, toxins, toxic wastes, toxic 

 venoms, etc., are subjected in the phagocytic leucocytes, the tissue cells, 

 the lymphatic system and the blood plasma to the catabolic phase of 

 metabolism, which serves to convert them into eliminable end-products. 



Crile (G. W.). The kinetic system, Cleveland M. J., Vol. XII, No. 4, October, 1913, 

 p. 665, associated with which is : 



Hitchings (F. W.), Sloan (H. G.), and Austin (J. B.). Laboratory studies of the brain 

 and the adrenals in response to specific stimuli, Ibidem, pp. 684-691. 



Crile (G. W.) andLower (W. E.). Anoci-association. W. B. Saunders Co., Phila., 1914. 



Gushing (H.). Psychic disturbances associated with disorders of the ductless glands. 

 Am. J. Insanity No. 5, 1912, special number, pp. 965-990. 



Sajous (C. E. de M.). Among other articles: Hypoadrenia as a cause of death in in- 

 fections and its treatment. Monthly Cyclopaedia and Medical Bulletin, Vol. IV, 1911, 

 pp. 725-729. Also his Internal secretions and the principles of medicine, 5th edition, 

 Phila., F. A. Davis and Co., 1912. 



Sajous (C. E. de M.). The theory of the internal secretions. The Practitioner, Feb., 

 1915, PP- 180-197. 



