PATHOLOGICAL ANATOMY OF THE HYPOPHYSIS 273 



experiments on diabetics who at the time were sugar-free. Here if the 

 tolerance limits for sugar were reduced as a result of the injection, we would 

 expect to see a recurrence of the sugar. Finally in respiratory experiments on 

 men there occurred regularly after the injection of pituitrinum, an increase 

 in the production of carbonic acid or of consumption of oxygen, but never 

 a distinct rise of the respiratory quotient. 



As example I cite the following experiment: Case Ti (Acromegaly) 



Date CO 2 O 2 RQ 



February 14... 257.5 342- o 0.753 



February 16.. 247.7 3 2 9-8 0.748 



40 min. after the injection of 2 cc. pit. inf 297.0 393-9 -754 



Whether the investigation was made a short or a long time after the in- 

 jection, there could never be observed a distinct rise of the respiratory quo- 

 tients. The increase in the respiratory metabolism that we found after 

 the injection of pituitrinum infundibulare may very well be referred to an 

 increased stimulation of smooth-muscled organs probably also to an in- 

 creased activity of the liver. At least the hyperemia of the liver that 

 E. Neubauer found in oncometric experiments seems to point that way. 



Miller and Dean Lewis state that intravenous or intraperitoneal injec- 

 tions of extracts of posterior (and anterior) lobes of the hypophysis in dogs 

 indeed may sometimes induce transitory, very weak, glycosuria; it is here 

 very questionable, however, whether this has anything to do with the in- 

 ternal secretion of the hypophysis. 



The extract of the glandular portion of the hypophysis was formerly 

 regarded as entirely without action. Ivkovic and / found, however, that one 

 of the extracts furnished to us for trial by the firm of Parke, Davis 6* Co. 

 possessed a pronounced depressor action; after the intravenous injection of 

 2 to 3 cc. of this extract there occurred a depression of the blood-pressure, 

 which latterly again returned spontaneously to the normal; previous ad- 

 ministration of atropine would not hasten this return to normal, but on the 

 contrary would retard it. When large doses of the extracts were used, in 

 two of our experiments the blood-pressure sank to zero, and there was 

 cessation of respiratory and cardiac action; in one of these experiments the 

 heart could be made to beat again by administration of pituitrinum in- 

 fundibulare; the blood-pressure gradually rose to normal again, and the 

 animal entirely recovered. Later Hamburger without knowing about our 

 experiments, likewise reported concerning the depressor action of the ex- 

 tract of the glandular hypophysis. In numerous experiments that Bern- 

 stein and 7 made on human beings since that time we could never demonstrate 

 a distinct sinking of blood-pressure after the subcutaneous or intravenous in- 

 jection of several cubic centimeters of this extract. Hence the dog seems 

 very much more sensitive in this direction. We did observe in human beings, 

 however, an extremely striking action. Shortly after the injection of a 



18 



