300 



THE DISEASES OF THE HYPOPHYSIS 



Blood count, Dec., 1909: Erythrocytes, 4,680,000 

 Hemoglobin, 9.34 gm. 

 Leucocytes, 9400 of which: 

 Polymorphonuclear neutrophiles, 56.3 per cent. 

 Lymphocytes, 31.3 per cent. 

 Large mononuclears, 7.9 per cent. 

 Eosinophiles, 3.3 per cent. 

 Mast-cells, 1.2 per cent. 



I tabulate these observations together with those of the other observations 

 reported in detail in this book, in the following list: 



Lately there are observations of Borchardt in four cases, in which he found 

 the red blood cells to be somewhat reduced, the leucocytes at the lower limits 

 of normal, the neutrophiles mostly markedly reduced, the eosinophiles 

 somewhat high, in one case up to 11.5 per cent. 



If we summarize all these cases, we find that there is mostly only a slight 

 reduction of erythrocyte count or none at all (or even after operation an in- 

 crease in the number of erythrocytes), while in all cases there was a not in- 

 appreciable reduction of hemoglobin; the leucocyte count is often diminished, 

 and in one case increased. Most important is the result of the differential 

 count of the leucocytes. Almost in all cases the number of neutrophilic 

 cells is, relatively, markedly reduced, while that of the mononuclears, and 

 especially the lymphocytes, relatively and also absolutely raised. The 

 eosinophiles show in many cases an appreciable increase. After operation 

 the leucocyte picture may revert to normal (Observation Si, XXXIV). 

 In two cases (Observations D and K.L.) there were, however, marked mono- 



