HYPOPHYSIAL DYSTROPHY 3OI 



nucleosis after the operation. In these cases the hemoglobin remained 

 markedly reduced after the operation. Perhaps the mononucleosis is the ex- 

 pression of a slight grade of status lymphaticus. The blood-count in general, 

 as far as mononucleosis and poverty in hemoglobin are concerned, is similar 

 to that of myxedema. 



I enter more in detail into the consideration of a symptom which up to 

 the present has not been sufficiently regarded in the differential diagnosis. 

 I refer to the inhibition of growth. Already v. Frankl-Hochwart emphasized 

 that the cases of tumor of the hypophysis without acromegaly in youth 

 almost always affect small individuals. Almost in all cases in which the 

 disease began in the years between childhood and adolescent life is remain- 

 ing behind in growth reported. I here quote what I have been able to find 

 in this subject: 



Case of Berger. Began at twelve years. 



Case i of Bychowski. K. L., seventeen-year-old girl, very small, 132 

 cm. tall (operated on by v. Eiselsberg), cyst of the hypophysis. 



Case 2 of Bychowski. Reported very briefly. Growth ceased at the 

 age of thirteen years, 132 cm. tall. 



Case 2 of Nazari. Normal development up to between the sixth and 

 seventh years, then remaining behind in growth; at twenty years of age, 

 125 cm. tall. 



Case i of Babonneix and Paisseau. From eleven and one-half years 

 on, height remained stationary. 



Case i of Erdheim. Twenty-year-old woman, "body very small." 



Case of Zollner. One hundred forty-five centimeter tall individual. 



Case of Uhthojf. Dwarfism with bitemporal hemianopsia. 



Case i of Ettore Lem. Twenty-and-one-half-year-old woman, from ten 

 years old on cessation of growth, 130 cm. tall, lower length 71 cm., geni- 

 talia infantile, sella turcica considerably widened. 



Case i of Bartels. Twenty-one-year-old man, cessation of growth at 

 the fourteenth year. 



Case 2 of Bregman and Steinhaus. Seven-year-old girl, "relatively 

 small." 



Case of Mixter and Quackenboss. Twenty-seven-year-old man who 

 looks as if he were eighteen years old, enlargement of the sella, operation. 

 Epithel. congen. of the hypophysis with cystic degeneration. 



Case of Kummel. Twenty-three-year-old man, looks as if he were 

 fourteen years old, no obesity. 



Case of Leman and Van Wart. Twenty-four-year-old woman, infantile. 



Case of Bournier. Twenty-six year-old man, 125 cm. tall, eye disturb- 

 ances since his eighth year, disturbance of growth since his tenth year. 



Case of Rennie. Cessation of growth at the same time as the appearance 

 of manifestations of hypophysial tumor. 



