302 THE DISEASES OF THE HYPOPHYSIS 



Own Observation XXXIII (L). One hundred thirty-one centimeters 

 tall since ten years old. Has not grown for two years. 



Own Observation XXXIV (Si} .Sixteen-year-old girl, 145 cm. tall. 



Own Observation XXXVII (ScH). At the beginning very marked growth, 

 cessation of growth at thirteen years of age. 



Also the cases of dystrophia adiposo-genitalis with brain processes in 

 which a limitation of the function of the hypophysis may be suspected, show 

 the inhibition of growth. 



Case of E. Muller. 



Case i of Goldstein. Cessation of growth at the fifth year. 



Also Case 3 of Goldstein is called "small." Both were diagnosed serous 

 meningitis. 



Case 2 of Neurath. Scarlet fever at seven years of age, shortly afterward 

 cessation of growth; at ten years of age 109 cm. (instead of 130 cm.), prob- 

 ably hydrocephalus due to meningitis (see later, case Fr, Observation 

 XLIV). 



The following case may be regarded as a case sui generis of hypophysial 

 dwarfism : 



Case of Jutaka Kon. A thirty-seven-year-old "dwarfishy built man" 

 (147 cm. tall), could not visit the school on account of weakness of the eyes. 

 Now and then epileptic attacks, coarse, glittering face, skin dry, lately in- 

 creasing mental slowness, no hairiness on the mons Veneris, on the scrotum, 

 or near the lips. Genitalia entirely infantile. Autopsy showed a slight hy- 

 poplasia of the thyroid gland and an enormous calcified tumor of the in- 

 fundibulum, that histologically was a teratoma. The teratoma has existed 

 since earliest youth, it was "evidently congenital." 



The case of Benda was that of a thirty-eight-year-old dwarf. There was 

 found a hazelnut-sized teratoma of the hypophysis. The remnant of the 

 gland was atrophic, the genitalia were infantile. Here likewise there was a 

 teratoma, so that it is probable that it had existed since youth and was re- 

 sponsible for the dwarfism and the genital dystrophy. 



The case of Woods Hutchinson is correctly regarded by Breus and 

 Kolisko as chondrodystrophy. 



In the case of Hagenbach (sarcoma of the hypophysis in an individual 

 103 cm. tall) the connection between the growth disturbance and the tumor 

 of the hypophysis is, as the author points out, hard to show, as it is not known 

 when the tumor began to form. 



Aschner describes a case of dwarfism which he regards as hypophysial 

 entirely incorrectly. In this case there does not exist a single symptom that 

 points to this hypophysis. I regard this case as a true infantilism. 



The case of Hueter, quoted by Aschner, is quite uncertain. Hueter him- 

 self is of the opinion that the tuberculous disease of the hypophysis, in the 

 forty-two-year-old woman, is of recent date, and therefore has nothing to 



