ADDENDUM 327 



are statements as to the treatment of osteomalacia with pituitrinum infun- 

 dibulare (Bondi, Pal, Bab, Neu}. Its use as a cardiac and vascular tonic has 

 not as yet been tested. As when it is injected subcutaneously in man it can 

 increase blood-pressure not inappreciably and for a long time, tests in this 

 direction seem to me very desirable, the more so as disagreeable by-actions are 

 very much rarer than when adrenalin is used. As pituitrinum infundibulare 

 increases the respiratory metabolism, Bernstein and / have tried it in one case 

 of adiposity, without result. 



Pituitrinum glandulare has been tested but little. Very interesting is 

 the statement of Pal that two cases of osteomalacia that were treated with 

 extract of anterior lobe (Parke, Davis & Co.) improved essentially. 



Addendum 



The subject of acromegaly, always an interesting one, has been so 

 thoroughly dealt with by the author, and so much has been written about 

 it, especially in this country, by Cushing, that the editor feels he has nothing 

 to add. The author is perhaps a trifle misleading in the portion of the 

 chapter that deals with hypophysial dystrophy, conveying the impression 

 that all cases of pituitary tumor that cause this affection are associated 

 with the characteristic fat distribution. Whether this is so is "questionable, 

 although authors who have reported such cases do not always take pains 

 to deny that such a distribution is present, v. Frankl-Hochwart himself 

 did not find it in the case reports that he reviewed, and in some of these 

 reports an emaciation was spoken of. In eleven of his own cases it was 

 present pronouncedly in eight, and was only suggested or indicated in three. 

 v. Frankl-Hochwart points out that the cases more nearly approach the 

 classic types the earlier in life the disease sets in. 



Wolf stein in reporting a case of hypophysial tumor calls attention to the 

 importance of bitemporal hemichromatopsia in the early diagnosis. In this 

 author's case the pubic and axillary hair did not fall out, although there 

 was a sudden cessation of menstruation. 



Sweet and Allen have done apparent total hypophysectomy in dogs, with 

 characteristic changes in the animals but not death. They believe that in 

 the dog the entire gland can be removed without danger to life. 



Recent experiments of Herring make it appear as though there are two 

 separate active principles in the posterior lobe of the hypophysis. It is 

 probable that the active principle of the posterior lobe is a product of the 

 epithelial cells of the pars intermedia, and that there are in the pars nervosa 

 certain products of the breaking down of these cells. The substance acting 

 upon the uterus is formed at an early stage in the cells of the pars intermedia, 

 but the substance acting on the blood pressure and kidney is a later product 



