ADDENDUM 333 



The diagnosis of epiphysial tumors in adults is hardly possible, as the 

 symptoms produced are hardly to be distinguished from the tumors of 

 the neighborhood of the corpora quadrigemina. 



According to Marburg the possibility of an epiphysial tumor should be 

 thought of when there occurs associated symptoms of initial headaches 

 especially of the occipital region early choked disc, vertigo, sleeplessness, 

 convulsions, later, somnolence, paralysis of the eye muscles associated with 

 ataxia (Nothnagel) , and disturbances in hearing. What makes the diagnosis 

 the more difficult is that epiphysial tumors, as above mentioned, also lead to 

 dystrophia adiposo-genitalis, probably through limitation of the function of 

 the hypophysis. On the contrary, the diagnosis in childhood is possible, 

 through the combination of general brain tumor symptoms and those of 

 quadrigeminal lesion with those of premature development of the body, the 

 psyche, and the genital sphere, and was first made in vivo by v. Frankl- 

 Hochwart. The treatment by operation has not as yet been tried. 



Addendum 



Jordan finds no clear histological evidence indicative of a glandular func- 

 tion of the pineal body, and that if the pineal body in the sheep subserves an 

 important physiological function, this is probably active only 'during the first 

 eight months of postnatal life. Pineal bodies of sheep older than one year 

 present much variation and degeneration. 



An editorial in the Journal of the American Medical Society, Vol. LXVI, No. 5, 

 Jan. 29, 1916, p. 361, calls attention to the stimulating effects of pineal gland extracts 

 when administered to young animals, and to negative results following extirpation of 

 the pineal gland. The literature dealing with the material of this apparent incon- 

 gruence will be found in conjunction with Walter E. Dandy's article : Extirpation of the 

 pineal gland, Journal of Experimental Medicine, Vol. XXII, No. 2, Aug. i, 1915, p. 

 237-247. 



Jordan (H. .). The histogenesis of the pineal body of the sheep. Am. J. Anat., 

 Vol. XII, 1911-12, pp. 249-270. 



