ETJNUCHOIDISM 409 



is entirely absent, although it may be present slightly. In one of my cases 

 the inclination was at first contrasexual. In many cases potency can exist 

 for some time, but this becomes less after some years and disappears. In 

 other cases the inhibition of development and disturbance of function occurs 

 chiefly at the time of puberty and later becomes compensated (transitory 

 eunuchoidism). We may regard both as formes frustes. As a case of the 

 first form I would regard case II of Josef son and Lundquist. It was that of a 

 forty-five-year-old man who had been married since the thirty-sixth year and 

 who was entirely impotent for three years. The breasts had been very rich in 

 fat ever since youth and the pubic hairs ended above in a horizontal line, the 

 voice had not changed, the hairs of the beard and in the axillae were very 

 sparse, trunk hairless. 



Eunuchoids of the male and female sex are always sterile. At least no 

 case of procreation or conception is known. 



In woman, the breasts are poorly developed or fatty, but poor in glandular 

 substances; in man they often contain much fat. 



Observations on the respiratory metabolism have as yet been confined to 

 Observation H and to a female eunuchoid of L. Zuntz's. The value of O2 

 requirements is entirely normal. Of course from which we are not justified 

 in concluding that in such cases we may not have had a slight degree of 

 endogenous obesity, as small differences may not be evident on investigation, 

 and yet through summation may favor deposition of fat. It is certain that in 

 all these cases there is present an abnormal disposition for the deposition^ 

 fat, as was observed for example in the case of H. At all events the cause 

 may be due chiefly to the slight inclination for movement and to the indi- 

 vidual's phlegma. 



Test for alimentary glycosuria was undertaken in three of my cases, with 

 150-200 gm. dextrose, and always resulted negative. Hence the assimilation 

 limits for carbohydrates seem to be high. 



Guggenheimer reports a case in which at an old age diabetes developed. I 

 cannot see here an especial connection with eunuchoidism. In eunuchoidism 

 (as in normal individuals) there may very well set in a degeneration of the 

 pancreatic insular apparatus. Another case of eunuchoidism with diabetes 

 seems to be the "giant" described by Uhthojj. This. patient at the age of six- 

 teen years suffered an attack of pneumonia. From then an abnormal growth. 

 He was 194 cm. tall, hands and feet were not especially large. There existed 

 bilateral cryptorchidism, the pubic hairs were sparse, and he had never been 

 potent. 



The purin metabolism has been studied (not published) in one case only, 

 Observation H of N ' owaczinski and myself. The endogenous uric acid 

 elimination was normal. Purin administered exogenously was well elimi- 

 nated. Perhaps this behavior is of differential diagnostic importance as 

 against hypophysial dystrophy. 



