424 THE DISEASES OF THE SEXUAL GLANDS 



Still more significant are the experiments with homiotransplantation of 

 the ovaries. I refer to the collected statistics of Novak. It is true that in 

 most cases the result lasted only for a short time, but in animal experiments 

 numerous results of longer duration including maturation of the ovum and 

 conception have occurred. On experiments in man, I mention the two cases 

 that follow. Cranner transplanted into a twenty-one-year-old woman, who 

 had never menstruated and who possessed rudimentary mammae, the ovary 

 of an osteomalacic woman. Menstruation then set in and the breasts de- 

 veloped. Still more remarkable is a case of Halliday-Crom. In this case 

 amenorrhea had set in after labor and symptoms of absence developed. 

 The small cystic ovaries were removed and a foreign ovary implanted. 

 The woman again menstruated four months after the operation, and four 

 years after the operation she conceived and bore a normal child. This case 

 was earnestly discussed before the Edinburgh Obstetrical Society, and 

 cannot well be denied. There is indeed in this case no doubt that if there 

 has been no error of observation, this woman bore the child of another woman. 

 Serious objections might be raised against such procedures on ethical and 

 forensic grounds. 



m. HYPERGENITALISM 



Definition. We have come to know hypergenitalism already in the 

 chapters on the hypophysis and in the consideration of suprarenal cortical 

 tumors. There are also cases of premature development of the genitalia 

 associated with temporary excessive development of the organisms, in which 

 the epiphysis or the suprarenal cortex do not come into consideration as 

 etiological factors, but in which we must assume, with great probability, a 

 primary disturbance of the sexual glandular function on the sense of a pre- 

 mature occurrence or an excessive increase. 



Pathologico-anatomical Findings. A portion of these cases show malig- 

 nant tumors of the sexual glands. Neurath collects five cases from the litera- 

 ture, four ovarian tumors (two established at autopsy, two on operation) and 

 one testicle tumor (operation) . In another the sexual glands were described 

 as only extraordinarily large. I must state that in two cases hydrocephalus 

 was reported. One of the cases was reported by Wetzler; also in a case of 

 Pellizzi's did there exist, besides pronounced hypergenitalism and excess- 

 ive growth, hydrocephalus with convulsions. Whether these were cases 

 of primary hypergenitalism cannot in the present state of our knowledge be 

 answered. 



Symptomatology. The premature sexual development is found in both 

 boys and girls. Neurath, who has written an excellent essay on this subject, 

 quo'tes forty-three cases of premature sexual development in boys. In 

 such individuals an excessive development of the genitalia may occur al- 

 ready in the first year of life. 



