GIGANTISM 463 



role in the pathogenesis. In such cases there may indeed appear even 

 simultaneous manifestations of hypophysial insufficiency (confer the case 

 of Raymond and Claude}. But as I mentioned already at the beginning 

 the conception does not seem to me established as yet. I must leave open 

 the question as to whether the hyperplastic mapping out of the entire duct- 

 less glandular system is only a partial phenomenon of an abnormal mapping 

 out of the entire organism. We know indeed of a gigantism of individual 

 extremity masses. I refer to the communications of Fischer, Manasse, 

 Wiedenmann, Grunfeld, et al. We cannot hold the ductless glandular system 

 responsible for such an abnormal growth tendency, even though there are 

 found, also not rarely, certain anomalies of this system, e.g., cryptorchidism 

 on the same side. 



Addendum 



Parhon and Parhon would add paralysis agitans to the list of pluriglan- 

 dular diseases on the strength of certain Abderhalden tests in which the duct- 

 less glandular extracts in general, but especially those of thyroids and para- 

 thyroids, reacted positive to the sera of paralysis agitans patients. 



REFERENCE 



Parhon (C.S.), and Parhon (M.) : Untersuchungun iiber die Abderhaldensche Reaktion 

 bei der Parkinsonschen Krankheit. Fermentforschung, Vol. i, No. 3., p. 311-314. 



