CONTENTS 



PAGE 



List of Illustrations xv 



CHAPTER 



I. The Problem of Pattern i 



Pattern and Material. Organismic Pattern. The Origin 

 of Organismic Pattern. Physiological Correlation as the 

 Mechanism of Integration. Organismic Pattern and the 

 Chromosomes. Conclusion. 



II. The Physiological Basis of Axiate Pattern . 23 



The Physiological Gradient. The Evidence from Struc- 

 ture and Development. The Evidence from Suscepti- 

 bility. The Evidence from Rate of Penetration. The 

 Evidence from Certain Oxidation-Reduction Reactions. 

 The Evidence from Bioelectric Phenomena. The Evi- 

 dence from Oxygen Consumption and Carbon Dioxide 

 Production. Evidence for the Existence of Physiological 

 Gradients in Various Organs. 



III. The Origin of Axiate Pattern in Nature and 



Experiment 50 



The Origin of Polarity. The Origin of Symmetry. The 

 Problem of Cell Pattern. The Relations of Surface- 

 Interior to Axiate Pattern. Conclusion. 



IV. Excitation and Transmission in Relation to 



Axiate Pattern 67 



The Excitation Gradient. Theories of Excitation and 

 Transmission. Primitive Excitation Processes. The 

 Question of Reversibility. General Discussion. 



V. The Physiological Gradients in Relation to 



Organismic Integration 89 



The Physiological Gradient as a Basis for Differentiation. 

 Physiological Dominanccand Subordination in Relation to 

 the Axial Gradients. Physiological Isolation. Conclusion. 



xi 



