324 NASAL CAVITIES. 



Such complications as capillary bronchitis, broncho-pneumonia, and 

 gangrene of the lung may be noted. 



The mucous membrane of the mouth presents a violet-red or 

 blackish-red colour ; the tongue and gums are swollen, and ulcers 

 as large as a lentil or a halfpenny' may occur either singly or in a 

 confluent form. 



The genito-urinary apparatus reveals signs of croupal cystitis, 

 submucous effusions of blood, vaginitis with the formation of false 

 membranes, acute pyelitis, etc. 



Diagnosis. When the symptoms are fully developed the diagnosis of 

 gangrenous coryza is extremely simple, but the absence of some of these 

 may justify hesitation in forming an opinion. If the examination is 

 carefully carried out, it is always possible to distinguish this disease 

 from simple coryza, which is only accompanied by trifling fever, and in 

 which appetite is preserved ; from foot-and-mouth disease, with its very 

 characteristic buccal eruption and absence of lesions from the upper 

 portions of the respiratory tract ; and from contagious ophthalmia. 



Prognosis. Up to the present time the prognosis has always been 

 regarded as extremely grave, the mortality being sometimes as high as 

 from 90 to 100 per cent., and moreover the cases which recover are 

 invariably those of what is considered the chronic form. Sudden 

 sinking of temperature during the disease is an unfavourable sign. 

 From 1894 to 1900 Moussu never cured a single case, whatever his 

 method of treatment ; nevertheless, it now seems possible to regard the 

 condition a little more hopefully, provided that no incurable compli- 

 cation occurs before the beginning of treatment. 



Treatment. Of all the modes of treatment suggested — viz., anti- 

 febrile agents, general stimulants, purgatives, diuretics, external 

 stimulant applications, etc. — none have succeeded. Antiseptics in- 

 jected into the nasal cavities, antiseptics given internally, milk diet, 

 and all the methods hitherto suggested are equally useless. 



The only treatment which appears to have achieved any degree of 

 success is that of injecting physiological salt solution in large doses (up 

 to six quarts per da}^ divided into three parts). All the animals treated 

 by this method recovered, provided they presented no broncho-pulmonary 

 complications. 



The sole inconvenience of this treatment is the difficulty in carrying 

 it out when the animals are at a distance from the practitioner. It is 

 indispensable that they should be close at hand, in order that he himself 

 may make the injections at the proper time. There is some reason for 

 hoping, however, that serum from animals which have recovered will 

 prove to be more active than saline injections. 



This method of treatment should be followed up by the most rigid 



