Complications. Quarantine. 255 



This injection was followed by rubbing infectious saliva or blood into the nose, 

 and after five days 100 cc. of blood was again injected subcutaneously. Conti 

 immunized animals with 20 cc. of serum from animals which had recovered from 

 the diseas-e, to which 3 cc. of blood from an animal which had been affected for 

 47 hours with rinderpest was added. The author reports favorable results from 

 this method of immunization. 



Complications. Several years ago Koch (1904) and later Theiler 

 and Woolley, pointed out the dangers in the application of the simul- 

 taneous inoculation. In localities where piroplasmosis or trypano- 

 somiasis is prevalent there is the danger that parasites of the mentioned 

 diseases may be transmitted with the blood from cattle affected with 

 rinderpest, causing diseases from which the animals die ; thus in Egypt 

 in 1903 of animals which had been inoculated with serum obtained 

 in Constantinople (25 cc), and virulent blood (1 cc), 80-90% died 

 within a short time, and the losses appeared at least partially to be 

 caused by a piroplasmosis which resembled the East African coast 

 fever. The existence of this disease in Egypt has been established 

 by Koch (he therefore recommends large serum doses of 100 cc. to 

 be used repeatedly instead of the simultaneous inoculation). Theiler 

 also observed a mortality of 6.8% among 452 cattle in South Africa 

 which M^ere inoculated by the simultaneous method. In cattle coming 

 from localities free of Texas fever (124 head), for which a possible 

 piroplasma infection is much more dangerous, the loss amounted to 

 27.4%. As it is impossil)le in practice to exclude the blood from animals 

 which have recovered from Texas fever, but still contain in their blood 

 piroplasms, it was deemed advisable in the Transvaal to abstain from 

 the simultaneous inoculation, and serum has been used exclusively, by 

 which means an eradication of rinderpest was accomplished in 1903. 

 Woolley reports a case in which all of the 56 cows imported from 

 the United States to the Philippines died after the simultaneous inocula- 

 tion, probably from piroplasmosis, while according to Nesom's observa- 

 tions, in the Philippines, the otherwise effective simultaneous inocula- 

 tion causes a loss of 4% as a result of trypanosomiasis, which develops 

 after the injection. Spirillae, or the virus of heart water, may also be 

 the cause of possible bad results from this method. 



Veterinary Police. The safest prophylactic measure con- 

 sists in a quarantine against countries in which rinderpest pre- 

 vails. Since the practical application of this principle Western 

 and Central Europe have been freed of the disease, although 

 the plague lias appeared repeatedly in an epizootic form in 

 Russia and on the Balkan Peninsula. The introduction of the 

 disease may also be prevented to some extent by establishing 

 a carefully executed registration of cattle at the endangered 

 borders of the countries, which would considerably facilitate 

 the establishment of the origin of the disease, if it has been in- 

 troduced. 



If the disease should make its appearance in any locality 

 the immediate slaughter of all affected, as well as all exposed 

 animals, together with the thorough disinfection constitutes the 

 surest method for its eradication. If however such a procedure 

 cannot be executed it is advisable to segregate the infected 

 herds into small groups, keeping them completely isolated under 

 observation. (According to Piot-Bey better results were ob- 



