C:'2G Tuberculosis. 



Grosz noted a considerable difference in the two types after infection 

 of the scarified skin, the human type producing changes limited to 

 the area of inoculation and showing no tendency to become destructive 

 while the bovine type resulted in the formation of local ulcers followed 

 by involvement of the regional lymph glands and later of the internal 

 organs also, as a rule, with fatal termination. (Cutaneous inoculation 

 with the typus gallinaceus resulted in very slight local changes only.) 



Susceptibility of Man to Tuberculosis of Animals. Tender ordinary 

 conditions this question is, of course, beyond the possibility of experi- 

 mental demonstration. Nevertheless, our literature, and especially that 

 of more recent date, contains numerous reports of observations that 

 seem to justify the assumption of such susceptibility without even 

 taking into consideration of numerous instances in which typical bovine 

 bacilli were found in the lesions of tuberculous human beings. 



Tuberculous disease proceeding from injuries to the skin has 

 repeatedly been observed in persons who had the care of tuberculous 

 cattle or in veterinarians and meat inspectors who were employed 

 in inspecting or making post-mortem examinations of tuberculous 

 cattle. In the vast majority of cases (DeJong, Ravenel, Ostertag, 

 Jensen, Gratia, etc.) an injury of the finger or hand under such con- 

 ditions (in one instance injury of the face) resulted in the develop- 

 ment of a tuberculous nodule or ulcer at the point of infection, very 

 similar to those occurring from infection following injuries received 

 in the post-mortem examination of tuberculous human bodies. Occa- 

 sionally ( Johne, Krause, Troje) these local affections have been followed 

 by swelling of the lymph glands of the elbows and axillae. In a case 

 reported by "Weber the primary affection spread from the mucous 

 membrane of the gums to the tongue and the submaxillary gland. 

 Lassar calls attention to the fact that dermatitis verrucosa cutis is 

 a particularly frequent occurrence among persons employed in slaughter 

 houses, having himself observed 7 cases among 365 persons examined, 

 while otherwise the rate of morbidity is only 0.03%. In several cases 

 repeated applications of milk to the face resulted in dermal tuberculosis 

 (Grothau, Priester, Leloir, Salmon), while in one case 60 cold abscesses 

 developed on various portions of the body following an injury received 

 during milking. In this case there was also tuberculosis of the iris 

 which resulted in destruction of the eyeball (Coppez). Infections 

 of this character that have their origin in wounds of the articulations 

 are particularly dangerous and infections of finger articulations have 

 been observed to result in death from consumption (Pfeifer, Hartzell, 

 Salmon, Rich). 



On the other hand the experiments of an unknoAra physician are 

 worthy of mention, who treated persons affected with carcinoma with 

 cultures of bovine bacilli injected subcutaneously, with no observable 

 injurious results (Baumgarten). F. Klemperer, in experiments per- 

 formed on himself and on five tuberculous persons by repeated sub- 

 cutaneous injections of 0.25 cc. of an emulsion containing many bovine 

 bacilli, observed only local inflammatory symptoms but in no case 

 tuberculous lesions, while the injected bovine bacilli disappeared from 

 the tissues in a short time. Spengler also injected himself Avith i,^ mg. 

 of a bovine culture (subcutaneously) which resulted in an abscess that 

 broke after 34 days; suppuration continued for 8 months and was 

 sometimes quite profuse, but the lesion remained localized and the 

 regional lymph glands remained free. 



