Pathog'enesis. 



lymph glands or of other abdominal organs ; there may be, at 

 the most, slight swelling of the Ijnuph glands. In addition 

 to this, Hntyra showed that an alimentary infection was always 

 followed immediately by a distinct febrile reaction (see Fig. 

 115), that the bacilli of glanders may be present in the circulat- 

 ing blood on the 4th day after intestinal infection, and finally 

 that hematogenic 

 miliary nodules of 

 glanders (see p. 

 690) will develop 

 within seven days 

 following such an 

 infection. 



Since the inhal- 

 ation of virulent 

 cultures results in 

 infection of the 

 lungs, the possibil- 

 ity of natural infec- 

 tion taking place 

 through the respira- 

 tory organs can not 

 be denied. As a 

 matter of fact, how- 

 ever, experiments of 

 this kind (inhala- 

 tion of bouillon cul- 

 tures reduced to a 

 spray immediately 

 in front of the nos- 

 trils of a horse) re- 

 sult in the forma- 

 tion of nodules and 

 ulcers in the lower 

 portions of the nasal 

 cavities only, Avhile 

 the upper regions 

 remain perfectly in- 

 tact (Fig. 116) and 

 the lungs may con- . . , , ., i 



■fain Q? rwaih * ^ ^^"- ^^^^ t/Zondtrs nodules and ulcers on the lower 

 Idin, at most, ISO- portion of the nasal septum 16 days after inhalation of a 

 lated nodules. This boulUon culture of glanders bacilli— 36 hours' growth. 



observation sug- 

 gests that moist air, charged with bacilli, loses most or all of 

 them as a result of the whirling air currents immediately behind 

 the alae of the nostrils and that at most only a few bacilli ever 

 reach the deeper portions of the lungs in this manner. If we 

 consider in connection with this, that the virus of glanders is 

 rapidly destroyed after reaching the outer world and that con- 

 sequently the inspiration of dry air plays no role in the process 



