ft34 Douiiue. 



tive action of the remedy. Nevertheless there are reports which 

 appear to indicate the possibility of a recovery of the disease 

 processes following such treatment. 



Uhlenhuth & Woithc ssueceeded in keeping an artificially infected horse in 

 good strength for one year by increasing doses of atoxyl (0.3-5.0 gni. intravenously), 

 its blood, however, contained trypanosomes throughout the entire period in vary- 

 ing quantities, and it suddenly died from acute septicemia with extensive intestinal 

 hemorrhages. Eennes obtained better results in an artificially infected horse, which 

 he injected at intervals of 3-4 days, alternately with 4 gm. of atoxyl subcutaneously 

 and 3 gm. kalium tartaricum intravenously; after the administration of 32 gm. 

 atoxyl and 21 gm. kal. tart, the horse was permanently cured. Yakimoff treated 

 10 horses by injecting atoxyl ten times in succession, either subcutaneously (4-8 

 gm.) or intravenously (0.. 5-3.0 gm.), in increasing doses, and this treatment was 

 repeated. The results were good, as a relapse was observed in only one case. Monod 

 also is supposed to have succeeded in permanently curing an affected stallion with 

 similar treatment (first 0.5 gm. intravenously, then every second day an increase of 

 0.1 gm. until the maximum dose of 1.0 gm. was reached). 



The atoxyl solution must be freshly prepared at each application by boiling 

 on a water-bath. 



Of other arsenical preparations, Miessner fonnd in one 

 case arsenophenylglycin very effective, in Avliich the nutritive 

 condition and strength of an already greatly weakened animal 

 was materially improved by two injections of the remedy 

 (dose!) and the edematous swellings retrogressed. Frohner, 

 on the other hand, not only failed to observe an improvement 

 in one case after an intravenous injection of 24 gm. atoxyl, 

 bnt even noted severe symptoms of intoxication, snch as marked 

 psychic irritation, severe colic and on the second day nephritis. 

 Finally Monod reported lasting results in three stallions, which 

 in part were treated with arsen-trisulfid alone (15-30 gin. per os), 

 the others alternately receiving atoxyl. 



The local treatment of the swellings Avith astringent washes 

 and the suppuration of the testicles or lymph glands in accord- 

 ance with the rules of surgery are only of subordinate im- 

 portance. 



Prevention. Stallions and mares should be examined before 

 coitus as to their health, and horses with inflammatory changes 

 on the genital organs should be excluded from coitus on general 

 principles. Besides this it is advisable to wash the penis of the 

 stallion after every covering with a sponge dipped in clean 

 water. 



Veterinary Police. The veterinary police measures depend 

 on the principle that horses affected with dourine should be 

 excluded from breeding once and for all. Such measures appear 

 to be justified in spite of the possibility of a complete recovery, 

 by the frequent relapses and also by the fact that trypanosomes 

 may be present for months in the genital organs of apparently 

 recovered animals. Accordingly affected stallions should be 

 castrated, while affected mares should receive a distinctive 

 branding. The relatively late development of the symptoms 



