KINETICS AND AUGMENTORS 29 



Dimethylamine, diethylamine, diphenylamine, 

 ethylenediamine, isoquinoline, and alloxan have 

 not this action. 



It may here be mentioned that in no instance 

 have we found an auxetic substance to be a 

 kinetic as well, and, vice versa, no kinetic ever 

 seems to be an auxetic. All the substances have 

 been tested for both actions. 



Augmentors. It has been pointed out that 

 certain of the kinetic alkaloids enumerated above, 

 especially atr opine, greatly augment the action 

 of the auxetic in inducing cell-division. Some 

 of the other kinetics were now tested to see if 

 they also had this augmenting action. The jellies 

 contained some powerful auxetic, such as supra- 

 renal extract, guanidine, or theobromine, but in 

 insufficient quantities for these substances to in- 

 duce divisions by themselves in the experimental 

 ten minutes. A certain amount of the kinetic 

 was then added to the jelly and films made, 

 the specimens being controlled by films from 

 jellies which did not contain any augmentor. 



Artificial : atropine . . . (0*7 c.c., 1 per cent) 



morphine . . . (0'2 c.c. ) 



pilocarpine . . (0*5 c.c. ,, ) 



quinoline . . . (1 c.c. ) 



Natural : choline . . . ( ) 



cadaverine . ( ) 



Erom the foregoing experiments it will be 

 seen that, while those substances which are 

 auxetics by themselves directly cause cell-division, 

 there seems to be no specific chemical grouping 

 contained in them which can produce this action. 



