32 EXCITORS OF CELL-DIVISION 



an injury has occurred. As has already been 

 shown by experiment, these substances cause the 

 proliferation of lymphocytes, leucocytes, and 

 certain epithelial cells ; in fact, we know by 

 in-vivo experiments that they can cause the 

 cell-proliferation of healing. If the wound or 

 damaged site becomes infected, after a time the 

 proteins produced by the autolysis are further 

 split up, and the primary amines and amino-acids 

 are produced. These agents may cause slight 

 proliferation, although they are not effective by 

 themselves on a microscope slide unless aug- 

 mented. Still, the exuberant granulations usually 

 seen in an infected wound may be caused by these 

 additional auxetics produced by the decomposition 

 of infection. 1 If the infected wound becomes a 

 very chronic one, cadaverine and choline may 

 also be produced. When this happens, judging 

 by the in-mtro experimentation, a great change 

 must occur. The action of the normal auxetics, 

 xanthine, etc., becomes greatly augmented. The 

 additional auxetics, methylamine, propylamine, 

 glycocoll, leucine, and tyrosine, even if not active 

 before, now become converted into powerful 

 excitors of cell-division; and from the fact that 

 cadaverine and choline excite amoeboid movements, 

 the proliferating cells may also be caused to 

 infiltrate. 



In conclusion it should be mentioned that it 

 has not been possible to test all strengths of the 

 several substances experimented with. Hence, 



1 It has already been shown (1) that while extracts of dead tissues 

 induce cell-division, their action is greatly increased if putrefaction 

 has set in. 



