62 RED BLOOD-CORPUSCLES 



auxetics ; and then only will those granular cells 

 divide which have developed centrosomes. 



But highly granular erythrocytes (nucleated 

 red blood-corpuscles) taken from the internal 

 organs of healthy mammals will divide in the 

 same manner as similar cells taken from the 

 peripheral blood in cases of anaemia. 



One point is of great interest. The size of the 

 granular erythrocytes (erythroblasts, normoblasts, 

 megaloblasts, gigantoblasts) seems to be an indi- 

 cation of the number of daughter cells to which 

 they give rise. And the more numerous the 

 larger cells are, therefore, the greater the degree 

 of the regenerative process, and probably also the 

 degree of the anaemia. In conditions of extreme 

 anaemia the granular erythrocytes commonly 

 divide into six daughter cells. In the blood from 

 internal organs of healthy persons the granular 

 red blood-corpuscles usually divide into two only. 

 In the blood of cases of secondary anaemia, there- 

 fore, there must be present, in the peripheral 

 blood, much free auxetic, probably globin and 

 creatine, and there must also be a considerable 

 reduction in the coefficient of diffusion in each 

 individual cell. A similar condition must also 

 be present in the internal organs in health, and this 

 is known to be the case post mortem, for a jelly 

 which will cause lymphocytes taken from the 

 finger to divide will kill the same cells if taken 

 from the portal vein. But it has not been found 

 possible so to reduce the coefficient of healthy 

 red cells from the peripheral blood artificially as 

 to cause them to divide. 



One interesting fact has been learnt by these 



