THE SYMPATHETIC SYSTEM 35 



conditions of the kidney and liver. In the same way, it 

 would be very useful to have various signs to enable us to 

 define the intervention of the sympathetic nervous system 

 in the symptomatology under observation. 



At the present time our observations are still very 

 indefinite. It is only fair to say, however, that the injection 

 of suprarenalin and of pituitrin (posterior lobe) has been 

 tried lately and has often given very interesting results. 

 Not only has the subcutaneous injection of suprarenalin 

 cardio vascular effects, which have been known for many 

 years, but it can, with or without the injection of sugar 

 give a glycosuria more or less marked (Blum) accompanied 

 by a hyperglycemia, the significance of which has been 

 very much in dispute. Somewhat similar to this supra- 

 renalin glycosuria is pituitary glycosuria which was dis- 

 covered by H. Claude and A. Baudouin. They consider 

 that glycosuria is a normal consequence of an intra- 

 muscular injection of the posterior lobe of the pituitary, 

 previously purified and the lipoids having been removed, 

 provided it is followed by a meal containing sugar (pre- 

 ferably one half hour afterwards); this glycosuria is 

 noticed particularly in patients suffering from arthritis, 

 is absent in tuberculous individuals and is more abundant 

 than suprarenal glycosuria under similar conditions. To 

 this glycosuria are added cardio vascular phenomena stud- 

 ied by H. Claude, R. Porak and Routier and consist in 

 more or less marked changes in the tension of the pulse. 

 H. Claude, together with R. Porak, has recently tried to 

 make biological tests of these re-actions of suprarenalin 

 and pituitrin so as to be able to bring out lesions of these 

 glands in mixed glandular syndromes. For instance, the 

 glycosuria and cardio vascular re-actions, following the 

 injection of pituitrin are absent in acromegalia. In patients 

 with Basedow's disease, the cardio vascular re-actions are 



