50 ENDOCRINE GLANDS 



hormones has enabled us to understand how certain types 

 of organo therapy exert a stimulating action on other 

 glands than the ones injected. If the conception of 

 Chalones suggested by Schsefer is ever proved ; if it is ever 

 established that certain endocrine glands, have under 

 certain conditions an inhibitive effect on other glands, 

 then the therapy of glandular hyperfunction or dyshyper- 

 function will have made a great step forward. This 

 chapter is, however, only at its beginning. 



There are cases, becoming more and more numerous, in 

 which, organo therapy must be complex. I have already 

 insisted too much on the importance of polyglandular syn- 

 dromes and the frequency of a simultaneous alteration of 

 several glands, to say more on this subject. We must 

 oppose an associated organo therapy to multiple func- 

 tional disturbances. In some cases, it is best to give each 

 one for a certain period, in other cases the extracts of 

 various glands should be given simultaneously. I find 

 more and more, that I have to use preparations containing 

 a combination of: thyroid, pituitary, ovarian and adrenal 

 in varying proportions. When administered in syndromes, 

 such as, Dercum's disease, glandular obesity, sclerodermia, 

 certain cases of infantilism, etc., these organo thera- 

 peutical preparations seem to act very favorably. It even 

 seems as if thyroid medication was better tolerated when 

 combined with either adrenal or pituitary extract. When 

 medication has to be carried out for a long period of time 

 the association of these extracts is particularly indicated. 



W r e must finally remember that the good or bad results 

 of organo therapy can occasionally help us in diagnosis; 

 this has been established by Gilbert and Carnot. It is by 

 means of this method that Leopold Levi and II. de Iloth- 

 schild have shown the numerous consequences of a mild 

 thyroid insufficiency. It is, also, by this method that the 



