THE SYMPATHETIC SYSTEM 75 



and even sudden death have been reported following its 

 use in individuals with degeneration of the myocardium 

 or valvular lesions. It is, therefore, important to test 

 out with small doses at the beginning of treatment. 



During the course of the treatment, the intolerance 

 manifests itself by the following symptoms : Acceleration 

 of the pulse, palpitations, heat waves, sweating, tremors, 

 loss of weight, diarrhea. As soon as they appear the 

 medication should be discontinued or at least consider- 

 ably reduced. These symptoms of intolerance are more 

 frequent in adults than in children. 



THE SYNDROMES OF HYPERFUNCTION 

 OF THE THYROID. 



I. EXOPHTHALMIC GOITRE. 



Exophthalmic goitre is a disease characterized by the 

 following signs: hypertrophy of the body of the thyroid, 

 exophthalmos, tachycardia and tremors. To these are 

 added a number of secondary signs, the majority of 

 nervous origins, which give quite a peculiar appearance to 

 this disease. 



It is also called Basedow's disease in spite of the fact 

 that this condition was first described by Flajani in Italy 

 and afterwards by Parry and Graves in England. 



It occurs most often in women between the ages of 20 

 and 40, usually associated with a nervous stigma or an 

 iniDressionable character. 



SYMPTOMS. 



They begin very slowly and very progressively. The 

 first noticed are nervous manifestations. The patient 

 becomes peculiar and irritable. Her immediate friends 

 notice a change in the patient. She complains of waves 



