154 ENDOCRINE GLANDS 



low blood pressure and an anemia. They are really suf- 

 fering from a hyposecretion of the adrenals and are 

 improved by organo therapy. 



This conception of congenital or acquired adrenal de- 

 bility helps to explain the intolerance of certain subjects 

 to the administration of arsenobenzol (Milan) or anti- 

 typhoid vaccination (Lian, Loeper, Mery and Halle) . The 

 efficacy, both as a preventative and as a curative of 

 suprarenalin proves the origin of these phenomena. 



6. ADRENAL INSUFFICIENCY AND MUSCULAR SYN- 

 DROMES. The muscles utilize adrenalin. Carnot and 

 Josserand have shown that in order to produce the same 

 increase in the arterial pressure, it was necessary to give 

 three times as large a dose in the artery as intravenously, 

 because suprarenalin when injected in the artery goes 

 through the muscles which utilize it. 



In the same manner, a dose of suprarenalin sufficient 

 to raise the blood pressure when injected intravenously 

 is without effect when injected into the arteries. 



This enables us to understand how muscles deprived 

 of suprarenalin, suffer in their nutrition (my asthenia) 

 and in their functions (amyotrophy). We have seen how 

 certain tuberculous patients suffering from slow adrenal 

 insufficiency present a marked emaciation of the muscles, 

 a diffuse amyotrophy (Sezary) which contrasts with the 

 amount of subcutaneous fat. 



Certain cases of myasthenia which are included in the 

 syndrome of Erb-Goldflam, characterized by a muscular 

 asthenia, (weakness of the muscles, tendency to be easily 

 tired), either diffuse or limited to certain muscles of the 

 face, are probably due to some adrenal disturbance. 

 They improve under adrenal medication, alone or com- 

 bined, with thyroid or pituitary extract. 



