190 ENDOCRINE GLANDS 



2. NERVOUS THEORY ORIGIN. According to this the 

 glycosuria is due to an irritation or a lesion of the base of 

 the brain. At the level of the pituitary, there is a centre 

 which regulates glycogenesis ; there is also one in the bulb 

 and in other portions of the brain. The frequency of 

 glycosuria in cerebral hemorrhages or meningitis is well 

 known, as is also the case in brain tumors. 



Aschner believes that the glycosuria is due to a 

 lesion at the base of the third ventricle at the level of 

 the tubercinereum. 



Camus and Roussy, think that so-called pituitary 

 glycosuria is due to the irritation of regulating cerebral 

 centres located in the inter peduncular gray matter. 



VI. PITUITARY POLYURIA. 



As in the case of glycosuria, polyuria has been noted in 

 the course of acromegalia, infantilism. In Frohlich's 

 syndrome it is sometimes found without glycosuria. It 

 has occurred after traumatic lesions of the pituitary 

 (Frank) ; it may be caused by a solitary tubercle (Haushal- 

 ter and Lucien) or by a secondary carcinoma (Simmonds). 



Clinically, this polyuria is very variable. It may vary 

 from 2 to 8 liters daily. The quantity varies from day to 

 day. The diuresis which follows the ingestion of liquids 

 is slower than in normal individuals. For this reason, 

 the quantity of urine secreted during the night is more 

 abundant than normal (Berge and Schulmann). There 

 is not always any relationship between ingestion of liquids 

 and the amount of urine excreted. The polyuria is not 

 necessarily accompanied by polydipsia and the excretion 

 can be superior to the absorption. In other words, the 

 pituitary polyuria consists essentially in a disturbance in 

 the mechanism regulating the water and the exaggeration 

 of its elimination. 



