THE SYMPATHETIC SYSTEM 231 



The menses are irregular and scanty. Sometimes, at the 

 menstrual period, they have symptoms of hyperthyroid- 

 ism: tachycardia, tremors, nervosity, etc., indicating a 

 certain degree of thyroid instability. The menopause in 

 these women occurs very early in life. They cease 

 menstruating at 25 or 30. 



In other cases, there is a hyperf unction of both the 

 thyroid and the ovary. The menses are early, last a long 

 time and are very abundant. In some cases, there' is 

 alternatively hypo and hyperactivity of the ovaries: the 

 menses are ahead of time, but are scarce or late and 

 excessive. There is a disequilibrium of the ovarian 

 functions or ovarian ataxia, as described by Jayle. 



TREATMENT OF OVARIAN INSUFFICIENCY. 



1. Ovarian graft would appear to be the most satis- 

 factory therapeutic method to prevent the various 

 phenomena following the removal of the ovaries. 



Grafts were first attempted on animals by Knauer and 

 Rubinstein, and in France by Limon, who showed that the 

 graft went through two distinct stages; first of degenera- 

 tion, then regeneration. Then Sauve found that the graft, 

 while histologically appearing to functionate, has a 

 different structure from the normal ovary and resembled 

 ectopic ovaries. All the physiologists agree that homo- 

 genous and heterogeneous graft nearly always fail and 

 that auto graft is the only method which has any chance 

 to succeed. 



Human grafts were first attempted by Morris. In 

 France Mauclaire, Delageniere, Tuffier and Sauve have 

 attempted it in the tubes or in the broad ligament, or in 

 the subcutaneous cellular tissue and even in the peri- 

 toneum (Tuffier). 



In a few cases the graft has been followed by an 



