ENDOCRINE GLANDS 



improvement of the symptoms and a re-establishment of 

 the menstrual flow. Pankow has shown histologically the 

 vitality of a graft after three years. 



In very exceptional cases the graft has been followed 

 by pregnancy. The observation of Morris is classical: 

 a woman on whom he had performed a double ovariotomy 

 and at the same time a heterogeneous graft in the broad 

 ligament, became pregnant four years afterwards and 

 gave birth to a full time child. 



These observations are, however, not as convincing as 

 we might think, for the return of menstruation after 

 castration, not followed by graft, is not exceptional and, 

 furthermore, small ovarian remains, or supernumerary 

 ovaries, left during the castration can explain the ulte- 

 rior pregnancy. 



As a matter of fact, most grafts are failures. Some are 

 painful and periodically become congested and painful 

 (Tuffier) so that while this method is of interest from a 

 biological and theoretical point of view, nearly all surgeons 

 have given it up. 



2. Ovarian organo therapy can be used: 



(a) By using the fresh gland of the sheep in doses of 

 from 2 to 3 grams daily. This method of administration 

 is usually not well tolerated. 



(6) Ovarian powder in doses of from 0.10 to 0.50 centi- 

 grams daily, or the extract of the corpus luteum in smaller 

 doses (0.02 centigrams for 5 or 6 days). These are the 

 most commonly used preparations. 



(c) Glycerin extracts for injections do not appear to be 

 any better. 



Ovarian organo therapy only succeeds in cases of hypo- 

 function of the ovary. It can then attenuate the 

 menstrual pains, regulate the menses, decrease the obesity, 

 even improve the psychoses of puberty or menstruation. 



