246 ENDOCRINE GLANDS 



THIRD GROUP. 



This is characterized by the association of several uni- 

 glandular syndromes without any marked predominance 

 of any. 



This group has been studied by Claude and Gougerot in 

 the case of a man first affected by genital atrophy and loss 

 of hair on the pubis and axilla and who in a few years 

 showed a progressive asthenia accompanied by arterial 

 hypotension, with thickening of the skin and an abnormal 

 pigmentation of the skin. Autopsy revealed lesions of 

 several glands: thyroid, testicles, adrenals, pituitary; 

 thus explaining the pluriglandular symptomatology of the 

 patient. In this observation, there was no predominance 

 of any one gland. 



ETIOLOGY. 



Pluriglandular syndromes may be the result, more or 

 less delayed, of an infection: typhoid, rheumatism, 

 scarlet fever, malaria, of alcoholism, of renal or hepatic 

 lesions (cirrhosis, biliary, hypertrophy, etc.) of acquired 

 or congenital lues and of tuberculosis. 



A certain predisposition of the endocrine system seems 

 to be necessary. They are more often met with in men 

 with a moderate sexual appetite or women with irregular 

 genital functions. 



SYMPTOMATOLOGY. 



One of the most frequent types is the syndrome of 

 pluriglandular insufficiency of the thyroid, testicle 

 and adrenal. 



The condition starts very gradually in individuals, who 

 up to then had had a normal activity and good health. 

 They become listless, complain of general weakness or 

 have genital disturbances: sexual desire decreases and 



